_____ caused a large decline in the Roman population during the years 541-588 CE.

Name: _____ caused a large decline in the Roman population during the years 541-588 CE.
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The best choice is pandemics, specifically the outbreak of the bubonic plague known as the Plague of Justinian. This disease caused widespread illness and death throughout the Byzantine Empire, including in the city of Rome, leading to a significant decline in the population.

_____ Caused a Large Decline in the Roman Population During