The research subjects in the Tuskegee Syphilis Study were informed that they had syphilis before the study began.

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The subjects were not informed that they had syphilis before the study began. In fact, they were intentionally misled and told that they were receiving free medical care for "bad blood." This unethical and harmful study was conducted from 1932 to 1972, mainly on poor African American men in Tuskegee, Alabama, without their informed consent or proper treatment for their syphilis. The study was one of the most notorious examples of human research exploitation and racism in the history of medicine.

The Research Subjects in the Tuskegee Syphilis Study Were Informed