The ECMO specialist has noticed excessive clotting in the circuit despite increase doses of heparin. What is the most feasible explanation for this event?

Question

Quizplus · Accepted Answer

If excessive clotting in the circuit is noted, a deficiency in ATIII is a possible cause. Heparin has no direct anticoagulant effect on the blood by itself but combines with a cofactor, antithrombin III (ATIII), to prevent thrombi from forming. This stops the conversion of fibrinogen to fibrin and ultimately prevents blood from clotting. A deficiency in ATIII can cause heparin to be ineffective, resulting in the use of excessive amounts of heparin.

The ECMO Specialist Has Noticed Excessive Clotting in the Circuit