Which of these is thought to be a causative factor of spina bifida?

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Spina bifida is a neural tube defect caused by an incomplete closure of the vertebrae and neural tube;the meninges and spinal cord protrude through the opening secondary to maternal folic-acid deficiency.The degree of neurological impairment depends on the location and the size of the defect.The infant may have hydrocephalus and genitourinary and orthopedic defects.Surgery is required.The infant's membranous sac must be assessed for intactness.The infant must also be assessed for reflexes and neurological impairment.

Which of These Is Thought to Be a Causative Factor