In von Willebrand disease, which is either autosomal recessive or autosomal dominant, clotting time slows and the person bruises and bleeds easily. Not everyone who inherits the disease genotype actually develops the phenotype. Affected individuals have differing degrees of difficulty in blood clotting. This condition is
A)completely penetrant, variably expressive, and not genetically heterogeneic.
B)incompletely penetrant, variably expressive, and genetically heterogeneic.
C)completely penetrant, invariably expressive, and not genetically heterogeneic.
D)pleiotropic and genetically heterogeneic.

Question

Quizplus · Accepted Answer

The disease phenotype is not always expressed in those who inherit the disease genotype (incompletely penetrant) and the severity of the symptoms (easy bruising and bleeding) can vary between affected individuals (variably expressive). Additionally, there are different types of von Willebrand disease that can be caused by mutations in different genes (genetically heterogeneic).

In Von Willebrand Disease, Which Is Either Autosomal Recessive or Autosomal