Which of the following chromosomal abnormalities most severely affect a fetus?
A)XXX
B)Monosomy for a large autosome
C)Trisomy 21
D)XXY

Question

Which of the following chromosomal abnormalities most severely affect a fetus?
A)XXX
B)Monosomy for a large autosome
C)Trisomy 21
D)XXY

Quizplus · Accepted Answer

Monosomy for a large autosome, such as monosomy 13, 18 or 21, can result in miscarriage or stillbirth. Surviving infants often have significant birth defects and intellectual disabilities. Trisomy 21 (Down syndrome) and XXY (Klinefelter syndrome) can also result in developmental issues but are generally less severe than monosomy for a large autosome. XXX is a sex chromosome abnormality that usually does not result in significant developmental issues.

Which of the Following Chromosomal Abnormalities Most Severely Affect a Fetus