In natural populations, the assumptions of the Hardy-Weinberg principle are usually met.

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While the Hardy-Weinberg principle provides a useful theoretical framework for understanding gene frequency changes in a population, it is rare for all of the assumptions to be met in natural populations. Factors such as selection, mutation, genetic drift, and migration can all cause deviations from equilibrium, leading to changes in allele frequencies over time.

In Natural Populations, the Assumptions of the Hardy-Weinberg Principle Are