In colon cancer,the complete loss of function of the p53 gene requires

Question

Quizplus · Accepted Answer

The p53 gene is a tumor suppressor gene that helps regulate cell division and prevent the formation of cancer. In colon cancer, it is common to see mutations in the p53 gene. However, a complete loss of function of the p53 gene requires a second mutation in the remaining copy of the gene, resulting in both copies of the gene being defective. This theory is known as the two-hit hypothesis, and it suggests that at least two mutations are required to completely lose the function of the p53 gene. Therefore, the best choice is at least two mutations (choice B).

In Colon Cancer,the Complete Loss of Function of the P53