You Are Designing a Drug

You are designing a drug.You'd like to deliver the drug by creating a skin patch that is impregnated with the drug and allowing the drug to diffuse through the layers of the skin to reach the underlying tissues and bloodstream.Which of these chemical changes might you make to increase the number of drug molecules that diffuse through the layers of skin cells?

A) Increasing the number of ionized groups in the drug
B) Increasing the number of nitrogen atoms in the drug
C) Decreasing the number of nonpolar groups in the drug
D) Decreasing the number of polar groups in the drug
E) Increasing the number of oxygen atoms in the drug