If an Individual Was Lacking a Key Amino Acid and So

If an individual was lacking a key amino acid and so couldn't make and release substance P,what would happen?

A) They would experience a lack of sensation in some pain pathways.
B) There would be a surge in activity in neurons that synthesize opiate neurotransmitters.
C) Synaptic activity in afferent neurons associated with pain receptors can be inhibited by axon-axon synapses with neurons from descending pathways.
D) There would be an increase in activity in neurons that detect painful stimuli in internal organs.
E) There would be increasing sensation of pain generated by the brain,with or without any damage to structures in the periphery.