The key difference between fetal hemoglobin and adult hemoglobin is that fetal hemoglobin has a lower affinity for oxygen because the levels of oxygen in placental blood is 2 to 3 times higher than other systemic arteries.

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Fetal hemoglobin has a higher affinity for oxygen than adult hemoglobin due to the presence of gamma globin chains instead of beta globin chains. This allows for efficient oxygen transfer from maternal blood to fetal blood despite the lower partial pressure of oxygen in maternal blood.

The Key Difference Between Fetal Hemoglobin and Adult Hemoglobin Is