Total-body balance of water and Na⁺ is largely maintained by regulating urinary loss of these substances.

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The regulation of urinary loss plays a major role in maintaining the balance of water and sodium in the body. Other mechanisms that contribute to fluid and electrolyte homeostasis include thirst, hormonal control, and renal function. However, urinary excretion is a key process that helps to adjust the body's water and sodium levels in response to changes in intake or loss of these substances.

Total-Body Balance of Water and Na⁺ Is Largely Maintained by Regulating