The gene on the Y chromosome that determines whether gonads will be testes or ovaries codes for a protein called Müllerian-inhibiting substance.

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The gene on the Y chromosome that determines whether gonads will be testes or ovaries codes for a protein called the Testis-determining factor (TDF), also known as SRY (Sex-determining Region Y) protein. Müllerian-inhibiting substance (MIS), also known as Anti-Müllerian Hormone (AMH), is produced by the testes after they have begun to differentiate and leads to the regression of the Müllerian ducts in the male embryo.

The Gene on the Y Chromosome That Determines Whether Gonads