Clifton,77 years of age,takes phenytoin to control his seizures.What age-related change may alter distribution and necessitate changing his dose?

Question

Quizplus · Accepted Answer

As people age, their production of albumin decreases, which can alter the distribution of phenytoin and require a change in dosage. Phenytoin is highly protein-bound, and decreased levels of albumin can lead to more free drug in the bloodstream, increasing the risk of adverse effects. Age-related changes in lung function, GI motility, and renal function may affect drug metabolism and elimination, but they are less likely to impact distribution.

Clifton,77 Years of Age,takes Phenytoin to Control His Seizures