The descending limb of the nephron loop is usually in osmotic equilibrium with the interstitial fluid.

Question

Quizplus · Accepted Answer

The descending limb of the nephron loop is permeable to water but not to solutes, and therefore water passively moves out of the tubule and into the interstitial fluid, leading to an increase in tubular fluid osmolality. As a result, the tubular fluid becomes progressively more concentrated as it descends into the medulla, approaching the osmolality of the interstitial fluid. Therefore, the descending limb of the nephron loop is usually in osmotic equilibrium with the interstitial fluid.

The Descending Limb of the Nephron Loop Is Usually in Osmotic