According to the WHO,the greatest global root cause of risk of disease is

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The WHO has identified poverty as the biggest global root cause of risk of disease. Poverty affects access to healthcare, nutrition, clean water, and sanitation, which contribute to the prevalence of a wide range of diseases. Additionally, poverty often leads to hazardous living and working conditions, which can also contribute to poor health outcomes. While infectious diseases, cancer, and heart disease are all significant health concerns, poverty is the underlying factor that exacerbates the risk for these and other health issues.

According to the WHO,the Greatest Global Root Cause of Risk