CASE HISTORY
Titus,a nine-month-old infant,suffered from a series of chronic problems after birth,including respiratory syncytial virus bronchiolitis (infection and inflammation of the bronchioles)and neonatal group B Streptococcal sepsis.(Neonatal sepsis happens soon after birth and is often caused by lancefield group B Streptococcus agalactiae,passed to the newborn from an infected mother. )As a result of his weakened state,Titus was fitted with a gastrostomy feeding tube so that his parents could feed him.Within a week of being sent home,however,Titus was rushed to the Johns Hopkins Hospital with an acute onset of fever,cough,regurgitation from his gastrostomy feeding tube,and dehydration.Physical exam confirmed that the boy had a severe cough resulting in respiratory distress,a rapid heart rate,and moderate dehydration.A nasopharyngeal aspirate (the nasopharynx is the nasal part of the pharynx)was positive for influenza A antigen.Titus was diagnosed with influenza and treated with the antiviral drug oseltamivir.He gradually improved and was discharged four days after admission.
What is the mechanism of action for the drug,oseltamivir,used to treat Titus's influenza infection? Why would antibiotics such as 50S ribosomal inhibitors have had no effect on this viral infection?
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