The direct consequence of a CD40 protein on a B cell binding to a CD40 ligand on a T cell is

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Quizplus · Accepted Answer

The direct consequence of CD40 protein on a B cell binding to a CD40 ligand on a T cell is the initiation of an intracellular signal required for B cell activation. This binding leads to the activation of the NF-κB pathway, which results in the upregulation of genes required for B cell proliferation, differentiation, and survival. This process is critical for the production of high-affinity antibodies and the development of effective humoral immunity. Heavy-chain class switching in the B cell is a downstream consequence of B cell activation, not a direct consequence of CD40-CD40L binding. Release of IL-2 from the T cell and release of perforins and granzymes from the T cell are not consequences of CD40-CD40L binding, but rather are associated with T cell activation and cytotoxicity.

The Direct Consequence of a CD40 Protein on a B