The dopamine hypothesis holds that excessive stimulation of D2 dopamine receptors along the mesocortical pathway results in the negative symptoms of schizophrenia.

Question

Quizplus · Accepted Answer

The dopamine hypothesis suggests that excessive stimulation of D2 dopamine receptors in the mesolimbic pathway, not the mesocortical pathway, is associated with the positive symptoms of schizophrenia. The negative symptoms are thought to be related to dopamine dysfunction in the mesocortical pathway, but not due to excessive stimulation.

The Dopamine Hypothesis Holds That Excessive Stimulation of D2 Dopamine