Why can't the large, negatively charged intracellular proteins (A-) permeate the cell membrane
A)They are greater than 0.8 nm in diameter and are not lipid soluble.
B)There are carriers for them.
C)No concentration or electrical gradient exists for them.
D)There are no positively charged ions to carry them.

Question

Quizplus · Accepted Answer

Large, negatively charged intracellular proteins (A-) cannot permeate the cell membrane because they are greater than 0.8 nm in diameter and are not lipid soluble. This means that they cannot passively diffuse through the hydrophobic lipid bilayer of the cell membrane. Instead, they require specialized transport mechanisms, such as ion channels or carrier proteins, to cross the membrane. However, even with these mechanisms, their size and charge can still present significant barriers to their movement across the membrane.

Why Can't the Large, Negatively Charged Intracellular Proteins (A-) Permeate