All of the following can describe why ED₅₀ and TD₅₀ values are not ideal for calculating a therapeutic index except:
A) the index uses a value based on 50% of subjects experiencing severe adverse effects.
B) the index uses a value based on only 50% of subjects experiencing therapeutic drug effects.
C) the index uses the ED₅₀ value, which is most common for reporting dose-effect curves.
D) no matter the size of the index, using 50% values suggests that an unacceptable number of patients will likely experience adverse effects.

Question

Quizplus · Accepted Answer

The statement "the index uses the ED₅₀ value, which is most common for reporting dose-effect curves" is false, as ED₅₀ values are only one of many ways to report dose-effect curves. The other statements are true and describe why ED₅₀ and TD₅₀ values are not ideal for calculating a therapeutic index.

All of the Following Can Describe Why ED₅₀ and TD₅₀