Analyzing the amount of psychoactive drug in brain tissue would allow a researcher to determine:
A) the drug's pKa.
B) the drug's active transport through the blood-brain barrier.
C) the drug's bioavailability.
D) the amount of biotransformation that took place.

Question

Quizplus · Accepted Answer

Analyzing the amount of psychoactive drug in brain tissue would allow a researcher to determine the drug's bioavailability, which is the amount of drug that is able to reach the brain and produce an effect. This information is important in determining appropriate dosing and understanding the drug's efficacy. The drug's pKa (A) refers to its ionization characteristics and is not directly related to its activity in the brain. Active transport through the blood-brain barrier (B) is one mechanism by which drugs can cross into the brain, but analyzing drug levels alone cannot determine this. Biotransformation (D) refers to the metabolism of a drug by the body and is not related to the amount of drug present in brain tissue.

Analyzing the Amount of Psychoactive Drug in Brain Tissue Would