The actions that cocaine has on dopamine neurotransmission consists of:

Question

Quizplus · Accepted Answer

Cocaine primarily increases dopamine levels in the brain by blocking the dopamine transporter, which is responsible for the reuptake of dopamine from the synaptic cleft back into the neuron. This blockade leads to an accumulation of dopamine in the synaptic cleft, enhancing its effects. Cocaine does not act as an agonist at dopamine receptors, nor does it inhibit dopamine synthesis or the action of COMT (catechol-O-methyltransferase), which is involved in the breakdown of dopamine. It also does not increase the passage of dopamine through vesicular transporters; rather, it allows dopamine to remain in the synaptic cleft longer by preventing its reuptake.

The Actions That Cocaine Has on Dopamine Neurotransmission Consists Of