A user may not be able to achieve the same high after long term use compared to when he started using the drug due to:

Question

Quizplus · Accepted Answer

Pharmacodynamic tolerance refers to the down-regulation of receptors in response to chronic drug exposure, which reduces the drug's effectiveness. This can result in a user needing to take higher doses of the drug to achieve the same high, and it is the most likely reason for diminished effects with long-term use. Cross-tolerance refers to a tolerance that occurs with one drug but also applies to another drug, whereas behavioral tolerance involves learning to function better despite being under the influence of a drug. Pharmacokinetic tolerance refers to changes in the body's ability to metabolize and eliminate the drug, which can impact the drug's duration and concentration in the bloodstream. While both of these can contribute to tolerance, they are less likely to be the primary reason for decreased effectiveness with long-term use compared to pharmacodynamic tolerance.

A User May Not Be Able to Achieve the Same