By inhibiting SK2 channels,chronic alcohol use:
A) reduces the risk of excitotoxicity if alcohol is withdrawn.
B) leads to decreased excitatory postsynaptic potentials.
C) leads to a down regulation of NMDA receptors.
D) promotes greater NMDA receptor activity if alcohol is withdrawn.

Question

Quizplus · Accepted Answer

Chronic alcohol use inhibits SK2 channels, leading to an increase in NMDA receptor activity. This increased activity can result in excitotoxicity if alcohol is suddenly withdrawn, indicating that chronic alcohol use does not reduce the risk of excitotoxicity. Therefore, option A is incorrect. SK2 channel inhibition leads to increased excitatory postsynaptic potentials, making option B incorrect. Chronic alcohol use does not lead to a down-regulation of NMDA receptors, so option C is incorrect.

By Inhibiting SK2 Channels,chronic Alcohol Use