Why might an opioid with substantial lipid solubility be a preferred recreational substance to an opioid with poor lipid solubility?
A) The poor lipid solubility drug doesn't bind well to opioid receptors.
B) The poor lipid solubility drug will be metabolized more quickly.
C) The poor lipid solubility drug passes more slowly through the blood-brain barrier.
D) The poor lipid solubility drug is rapidly eliminated from the body.

Question

Quizplus · Accepted Answer

Opioids with substantial lipid solubility can easily pass through the blood-brain barrier and reach the central nervous system quickly, leading to a more rapid onset of effects. In contrast, opioids with poor lipid solubility will pass through the barrier more slowly, leading to slower onset and a less intense high.

Why Might an Opioid with Substantial Lipid Solubility Be a Preferred