Phencyclidine has become an important experimental model for the ____________ hypothesis of schizophrenia.

Question

Quizplus · Accepted Answer

The glutamate hypothesis of schizophrenia proposes that dysfunction in glutamatergic neurotransmission plays a role in the pathophysiology of the disorder. Phencyclidine (PCP) is an NMDA receptor antagonist that blocks glutamatergic neurotransmission, which can cause schizophrenia-like symptoms in healthy individuals. Thus, PCP has become an important experimental model for testing the glutamate hypothesis of schizophrenia.

Phencyclidine Has Become an Important Experimental Model for the ____________