The first antidepressant drug was …

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The first antidepressant drug was iproniazid, which was discovered in 1952. It was originally developed as a treatment for tuberculosis but was found to have mood-lifting effects. It worked by inhibiting the enzyme monoamine oxidase, which breaks down neurotransmitters such as serotonin and dopamine. Iproniazid was later replaced by newer generations of antidepressants such as imipramine and fluoxetine. Pentobarbital is not an antidepressant drug but rather a barbiturate used as a sedative and hypnotic.

The First Antidepressant Drug Was …