A patient who does not improve on an antidepressant medication despite many attempts with different antidepressant drugs would be identied as…

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If a patient has not improved on multiple attempts with various antidepressants, they may be considered to have treatment-resistant depression. This means that their depression is not responding to traditional treatment methods and may require alternative approaches such as different medication combinations, psychotherapy, or brain stimulation therapy. Noncompliance, poor metabolism or misdiagnosis could certainly be factors in a lack of improvement, but if the patient has tried multiple antidepressants without success, treatment-resistant depression is a more probable explanation.

A Patient Who Does Not Improve on an Antidepressant Medication