A benzodiazepine will have long-lasting effects if…

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Quizplus · Accepted Answer

Active metabolites of benzodiazepines can prolong their effects, as they can continue to bind to the GABAA receptors and enhance inhibitory neurotransmission even after the parent drug has been metabolized and eliminated from the body. Poor lipid solubility would actually decrease the duration of action, as the drug would have difficulty crossing cell membranes and accessing its target receptors. Density of GABAA receptors and concomitant use of barbiturates may affect the potency and onset of action of benzodiazepines, but they do not necessarily determine their duration of effect.

A Benzodiazepine Will Have Long-Lasting Effects If…