An increased risk of suicide when first taking an antidepressant drug may be due to…

Question

Quizplus · Accepted Answer

Activation of presynaptic 5-HT₁A receptors when starting treatment with antidepressant drugs can lead to an initial increase in serotonin release, which may temporarily worsen symptoms such as agitation and anxiety and increase the risk of suicidal thoughts and behaviors. However, this effect usually subsides over time as the brain adjusts to the medication. A and B are possible side effects of antidepressant medication, but they do not explain the specific increase in suicide risk seen at the start of treatment. D is incorrect as blocking serotonin transporters is the mechanism of action for most antidepressants and does not directly contribute to an increased risk of suicide.

An Increased Risk of Suicide When First Taking an Antidepressant