The primary mechanism of action for a typical antipsychotic drug is…

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Antipsychotic drugs primarily work by antagonizing D₂ receptors in the brain. This leads to a decrease in dopamine activity in certain areas of the brain, which can alleviate psychotic symptoms. The other options listed (agonism of D₂ receptors, antagonism of NMDA receptors, antagonism for 5-HT₂A receptors) may have some role in the action of antipsychotic drugs, but they are not the primary mechanism of action.

The Primary Mechanism of Action for a Typical Antipsychotic Drug