The serotonin-dopamine hypothesis states that a greater affinity for D2 receptors than 5-HT2A receptors is needed for atypical antipsychotic drug effects.

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The serotonin-dopamine hypothesis suggests that atypical antipsychotic drugs often have a higher affinity for 5-HT2A receptors than for D2 receptors, which is thought to contribute to their therapeutic effects and side effect profiles, distinguishing them from typical antipsychotics that primarily target D2 receptors.

The Serotonin-Dopamine Hypothesis States That a Greater Affinity for D2