Which genetic disease has been linked to a mutation of the tumor-suppressor gene?

Question

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The gene responsible for retinoblastoma has been mapped to the long arm of chromosome 13, and its DNA sequence has been extensively studied. This gene is known as a tumor-suppressor gene; the normal function of its protein product is to regulate the cell cycle so that cells do not grow uncontrollably. Hemochromatosis, familial breast cancer, and hemophilia A are not caused by a mutation of the tumor-suppressor gene.

Which Genetic Disease Has Been Linked to a Mutation of the Tumor-Suppressor