Which chemical mediator derived from mast cells retracts endothelial cells to increase vascular permeability and to cause leukocyte adhesion to endothelial cells?

Question

Quizplus · Accepted Answer

The biologic activity of platelet-activating factor is virtually identical to that of leukotrienes; namely, it causes endothelial cell retraction to increase vascular permeability, leukocyte adhesion to endothelial cells, and platelet activation. The other options do not accurately identify the chemical mediator derived from the process described in the question. Chemokines function primarily to induce leukocyte chemotaxis. Prostaglandins interact with the kinin system to stimulate nerve endings and cause pain, among other actions. Bradykinin is the most important product of the kinin system and causes vascular permeability, smooth muscle contraction, and pain.

Which Chemical Mediator Derived from Mast Cells Retracts Endothelial Cells