When antibodies are formed against red blood cell antigens of the Rh system, how are the blood cells destroyed?

Question

Quizplus · Accepted Answer

Antibodies against platelet-specific antigens or against red blood cell antigens of the Rh system coat those cells at low density, resulting in their preferential removal by phagocytosis in the spleen, rather than by complement-mediated lysis. These blood cells are not destroyed by complement-mediated cell lysis, phagocytosis by macrophages, neutrophil granules, or toxic oxygen products.

When Antibodies Are Formed Against Red Blood Cell Antigens of the Rh