How does the ras gene convert from a proto-oncogene to an oncogene?

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A point mutation is the alteration of one or a few nucleotide base pairs. This type of mutation can have profound effects on the activity of proteins. A point mutation in the ras gene converts it from a regulated proto-oncogene to an unregulated oncogene, an accelerator of cellular proliferation. Fusion, duplications, and proliferation of growth signals are not the cause of a ras gene converting to an oncogene.

How Does the Ras Gene Convert from a Proto-Oncogene to an Oncogene