What abnormalities lead to the mucus plugging seen in children with cystic fibrosis (CF)?
A)Excess mucus plugs the gut and keeps it from absorbing water effectively.
B)A weak inflammatory response allows bacterial to colonize the mucus.
C)Defective chloride secretion and excess sodium absorption thicken the mucus.
D)Pulmonary vascular remodeling occurs that leads to chronic hypoxia.

Question

Quizplus · Accepted Answer

Respiratory mucus in CF is dehydrated and viscous because of impaired chloride secretion and excess sodium absorption. The gut's ability to absorb water is not affected. The inflammatory response is active in this disease process. Pulmonary remodeling does lead to chronic hypoxia, but this is not related to mucus plugging.

What Abnormalities Lead to the Mucus Plugging Seen in Children