Which statements are true regarding the narrow chemical safety margin that infants demonstrate? (Select all that apply.)
A)The immaturity of tubules may diminish the response to antidiuretic hormone (ADH).
B)An immature tubular transport capacity impairs the excretion of potassium.
C)An immature tubular transport capacity impairs the reabsorption of bicarbonate.
D)The immaturity of tubules may diminish the response to aldosterone.
E)The safety margin begins to expand after 2 years of age.

Question

Quizplus · Accepted Answer

Because of a high hydrogen ion concentration, a limited ability to regulate the internal environment, and a lowered osmotic pressure, the infant's renal system has a narrow chemical safety margin. The immaturity and smaller surface area of the tubules also may diminish the water reabsorption response to ADH. An immature tubular transport capacity means that the ability to excrete a potassium load, reabsorb bicarbonate, or buffer hydrogen with ammonia does not become efficient until approximately 2 years of age.

Which Statements Are True Regarding the Narrow Chemical Safety Margin