Which of the following is true about Huntington disease?
A) Symptoms typically appear between the ages of 10 and 20 years.
B) Individuals have a 25% chance of inheriting the condition from an affected parent.
C) Many individuals have already had children before developing the disorder.
D) Most affected individuals are homozygous for the gene (HH).
E) Once symptoms appear, the disease progresses very rapidly.

Question

Quizplus · Accepted Answer

Huntington disease often manifests in adulthood, frequently after individuals have had children, which contributes to its transmission despite its severe consequences. Symptoms typically appear between ages 30 and 50, not 10 and 20. The inheritance chance from an affected parent is 50%, not 25%, because it is an autosomal dominant disorder. Most affected individuals are heterozygous (Hh), not homozygous (HH), for the Huntington gene. The progression of the disease is gradual over many years, not very rapid.

Which of the Following Is True About Huntington Disease