How might a change in DNA nucleotide sequence of a gene cause a genetic disorder?

Question

Quizplus · Accepted Answer

All of these are possible ways that changes in DNA could lead to genetic disorders. A change in one base pair can alter the amino acid sequence of a protein, potentially rendering it non-functional. Mutations may also alter the structure of a protein, causing it to fold improperly or not assemble correctly with other subunits, leading to dysfunction. Mutations could also cause a shortened or truncated protein, which may not be able to perform its intended function.

How Might a Change in DNA Nucleotide Sequence of a Gene