Areas with high frequencies of malaria infections usually have high frequencies of sickle cell carriers.

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This is because the sickle cell trait provides some protection against malaria. Individuals who carry one copy of the sickle cell gene are less likely to die from severe malaria than those who do not carry this gene. Therefore, in areas where malaria is prevalent, the sickle cell trait becomes more common due to the survival advantage it provides against the disease.

Areas with High Frequencies of Malaria Infections Usually Have High