A 45 year old man with a previous history of untreated follicular lymphoma developed multiple lymph nodes that were enlarging quickly.Biopsy of one of these nodes was performed,and a representative section is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

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Diffuse large B cell lymphoma is commonly seen in association with low grade lymphomas,such as chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)or follicular lymphomAThese neoplasms can transform to more aggressive,faster growing diffuse large B cell lymphomas.Ironically,higher grade lymphomas are sometimes easier to treat and cure,because the chemotherapy works better on rapidly dividing cells.

A 45 Year Old Man with a Previous History of Untreated