Synthesis of mRNAs in paramyxoviruses occurs through a single-entry mechanism, which is where the RNA-dependent RNA polymerase can only start transcription from the 3' end of the genome.Which of the following is a consequence of this mechanism?

Question

Quizplus · Accepted Answer

The single-entry mechanism of RNA-dependent RNA polymerase in paramyxoviruses, which starts transcription from the 3' end of the genome, naturally results in more mRNA being produced from the coding regions located closer to the 3' end. This is because the polymerase progressively loses efficiency as it transcribes toward the 5' end, leading to a gradient of mRNA abundance that favors genes located at the 3' end.

Synthesis of MRNAs in Paramyxoviruses Occurs Through a Single-Entry Mechanism