Reoviruses keep their genome sequestered inside the inner capsid throughout the entire infectious cycle.Which of the following is the best explanation for why do they not release the genome segments out into the cytoplasm?

Question

Quizplus · Accepted Answer

Releasing the double-stranded RNA segments out into the cytoplasm would activate the interferon response, which plays an important role in innate immunity and would likely trigger an antiviral response that could inhibit the replication of the virus. Keeping the genome sequestered within the inner capsid helps the virus to evade detection by the host immune system.

Reoviruses Keep Their Genome Sequestered Inside the Inner Capsid Throughout