Reoviruses have been used to study viral pathogenesis in mice.Using virus reassortants, which of the following has been shown to be a major determinant for infection of the nervous system in a mouse?

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Quizplus · Accepted Answer

By creating virus reassortants with different surface proteins, researchers have shown that the ability of reoviruses to bind to different host cell receptors is a major determinant for their ability to infect the nervous system in mice. This suggests that specific receptors for the virus are present on neurons or cells associated with the nervous system, and may help explain why some strains of the virus are more neurovirulent than others.

Reoviruses Have Been Used to Study Viral Pathogenesis in Mice