Which of the Following Describes the Major Distinguishing Feature of Poxviruses

Which of the following describes the major distinguishing feature of poxviruses when compared to other DNA containing viruses that replicate in eukaryotic cells?

A) They encode their own DNA polymerase.
B) They have large complex genomes that encode over 100 different proteins.
C) They have large complex virions.
D) They replicate exclusively in the cytoplasm of infected cells.
E) They encode a wide-variety of regulatory proteins.