Monkeys infected with a mutant of SIV that lacks the Nef coding sequence have reduced virus titers and less severe disease.

Question

Quizplus · Accepted Answer

This statement is true. The absence of the Nef coding sequence in SIV results in reduced virus titers and less severe disease in infected monkeys. Nef is an accessory protein that plays a critical role in virus replication and pathogenesis by manipulating host cell functions. Without Nef, the virus is unable to replicate efficiently and evade host immune responses, leading to milder disease outcomes.

Monkeys Infected with a Mutant of SIV That Lacks the Nef