The plasmids that are used to express the retroviral proteins in the packaging cell lines contain the packaging signal (y).

Question

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The plasmids used to express retroviral proteins in packaging cell lines do not contain the packaging signal (ψ). The packaging signal is necessary for the genomic RNA to be packaged into the viral particle, and it is typically found on a separate plasmid that carries the gene of interest to be delivered by the virus, not on the plasmids encoding the viral structural proteins.

The Plasmids That Are Used to Express the Retroviral Proteins