Diabetic neuropathy is thought to result from

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Glucose appears to compete with myoinositol in transport into the cell.Degradation of glucose to sorbitol and fructose (the polyol pathway)occurs in the nerves in the presence of hyperglycemia and insulinopenia.Elevated HbA₁c is not associated with diabetic neuropathy.Deficient neuronal insulin receptors are not responsible for neuropathy.Focal ischemic lesions of the nerves may have a role in diabetic neuropathy.

Diabetic Neuropathy Is Thought to Result from